By taking as a pretext the concept of scientifically engaged, or science-engaged, theology, this study presents theology as a hermeneutical approach to the scientific culture of any ages and as a way of communicating the Christian message in conversation with contemporary culture. So understood, scientifically engaged theology is but a new word for the traditional habit of drafting the message in culturally conditioned forms, for pastoral and missional purposes. In order to show that science-engaged theology is an important way of theologizing and a traditional form of doing so, the present study examines the contributions of several patristic (Basil of Caesarea, Gregory of Nyssa) and neopatristic (Dumitru Stăniloae, Vladimir Lossky, Panayiotis Nellas) authors, genuine trailblazers for contemporary science-engaged theology.